金驰生物Logo

新闻动态

公司新闻 您现在的位置:首页 > 新闻动态 > 公司新闻

喜讯:我公司运用蛋白质组学明确了大鲵活性肽抗衰老机制

喜讯:张家界(中国)金驰大鲵生物科技有限公司运用蛋白质组学明确了大鲵活性肽抗衰老机制。

金驰生物立足科研,深耕大鲵深加工产业,成功从大鲵体内提取出大鲵活性肽、大鲵低聚糖肽、大鲵玻尿酸。经科研团队的不懈努力,运用蛋白质组学明确了大鲵活性肽抗衰老机制。

摘要:为了探究大鲵活性肽抗衰老作用机制,利用非标记定量蛋白质组方法对去除高丰度蛋白质后的灌胃大鲵活性肽小鼠血清进行蛋白质组生物信息学分析。分析结果表明,去除高丰度蛋白质后的血清中共检测到 425 种蛋白质,其中 26 种蛋白质表达量变化显著(P<0.05)。这些差异表达的低丰度蛋白质参与 14 个生理过程、具有 6种分子功能、存在于 7 种细胞组分中。其中胞质四氢叶酸合成酶和肌糖原磷酸化酶显著增加(P<0.05),分别增加了 1.78 倍和 1.05 倍,黄嘌呤脱氢酶显著减少(P<0.05)了一半,这些酶表达量的增加或降低,可以减少体内自由基的量。这些数据表明,大鲵活性肽抗衰老的机制是减少机体内自由基而发挥作用。通过本研究,为大鲵活性肽的开发利用提供了基础数据。

Abstract:To investigate anti-aging mechanism of giant salamander bioactive peptides,label-free quantitative (LFQ) proteomics was used after high-abundant proteins were removed. The results of LFQ showed 425 low-abundant proteins in serum in mice, in which 26 proteins were differentially expressed (P<0.05), and covered 14 biological processes, 6 molecular functions and 7 cellular components. Tetrahydrofolate synthase and glycogen phosphorylase were up-regulated expressed significantly (P<0.05), while xanthine dehydrogenase was down-regulated expressed significantly (P<0.05). The regulated enzymes could scavenge the content of free radical. These results showed that the giant salamander bioactive peptides prevented aging by scavenging free radicals. In this study, the basic data were provided for the use of the giant salamander bioactive peptides.